Introduction:
In the intricate orchestra of life, proteins play the lead role. These molecular performers govern cellular processes, orchestrate signaling pathways, and determine health and disease. At Biogrithm, we specialize in Proteomics Services, unraveling the secrets encoded within these protein symphonies. Let’s explore how our advanced offerings harmonize with your research needs:

1.Proteome Profiling:
What it is: Proteome profiling involves analyzing the entire proteome from complex samples, such as complete cells, tissues, and body fluids.
Methodology: We perform sample digestion using sequencing-grade trypsin or alternative proteolytic methods. The resulting trypsin-digested peptide samples are then analyzed using nano-flow LC-MS/MS.
Applications:

2.Protein Identification: Uncover as many peptides and proteins as possible.
Quantitative Proteomics: Reference information for high-throughput protein quantification.
Protein Modification Analysis: Insights into post-translational modifications.
Biogrithm’s Approach: Our spectral counting method provides protein relative abundances. Additionally, our HPLC sample fractionation systems enhance protein sequence coverage and detection dynamic range1.

3.Precision Medicine Biomarkers:
Why It Matters: Precision medicine relies on integrating targeted drugs with biomarkers for early and actionable clinical insights.
Our Expertise: Biogrithm develops and delivers proteomic tools, services, and disease biomarkers. We provide not just data but sophisticated bioinformatics, offering biological insights2.

4.Total Protein Profiling and PTMs:
Comprehensive Suite: Biogrithm offers a wide range of analytical methods suitable for all protein-related research, regardless of sample type or species.
Post-Translational Modifications (PTMs): We delve into critical PTMs, including phosphorylation, glycosylation, and acetylation, guiding translational research3.

Real-World Impact:
Drug Discovery: Biogrithm identifies drug targets, assesses drug efficacy, and monitors treatment response.
Biomarker Discovery: We uncover disease-specific protein signatures for early diagnosis and personalized medicine.
Functional Insights: Researchers gain mechanistic insights into cellular processes and disease pathways.

Conclusion:
Biogrithm’s Proteomics Services empower researchers, clinicians, and pharmaceutical innovators. From protein identification to functional insights, we decode the language of life, one peptide at a time.

Unlock the secrets of proteins with Biogrithm.